What Causes Apert Syndrome?
The Apert syndrome cause is a random mutation on a single gene. This gene produces a protein called fibroblast growth factor receptor 2 (FGFR2), which affects how bones form as an embryo develops. When the protein mutates or changes, it can sometimes lead to premature fusion of bones in the skull, hands and feet.
Apert syndrome is a somewhat rare condition, occurring in about one of every 65,000 to 160,000 births. The condition affects males and females in equal numbers.
Most children who have Apert syndrome have no family history of the condition. Only one parent needs to carry the abnormal gene for it to be passed to a child. Some research suggests that increased paternal age may be a risk factor.